PRF vs PRP Microneedling – What’s the Difference & Which Is Better for Skin Rejuvenation?

In the ever-evolving world of aesthetic medicine, the quest for natural, effective skin rejuvenation has led to exciting advancements in treatments that harness your body’s own healing power. Among these, microneedling combined with platelet-rich therapies has emerged as a game-changer. But as the field progresses, a new question arises: PRF vs PRP Microneedling – which approach delivers superior results?

This comprehensive guide will break down everything you need to know about these two innovative treatments, helping you make an informed decision for your skin health journey.

The evolution from basic microneedling to enhanced platelet therapies represents a significant leap in regenerative aesthetics. While PRP (Platelet-Rich Plasma) has been the gold standard for years, PRF (Platelet-Rich Fibrin) is now gaining attention as the next generation of natural skin rejuvenation.

Both treatments use components from your own blood to stimulate healing and collagen production, but they differ significantly in their preparation methods and how they deliver results. Understanding these differences is crucial for choosing the right treatment for your specific skin concerns and goals.

What Are PRP and PRF? Understanding the Science

To appreciate the differences between these treatments, it’s essential to understand what each one is and how they’re created from your blood.

PRP (Platelet-Rich Plasma) is a concentrated substance derived from your blood through a centrifugation process. When you undergo PRP treatment, a small amount of blood is drawn (similar to a routine blood test) and placed in a special tube that contains anticoagulants. This tube is then spun in a centrifuge at high speeds, separating the blood into distinct layers. The platelet-rich plasma layer is extracted and used for treatment. PRP contains a high concentration of platelets, which are natural reservoirs of growth factors that play crucial roles in healing and tissue regeneration.

PRF (Platelet-Rich Fibrin) represents the next evolution in platelet therapies. “PRF microneedling is an advanced form of PRP treatment that releases growth factors gradually for longer-lasting skin rejuvenation.” The key difference lies in the preparation: PRF uses a slower centrifugation speed and, crucially, no anticoagulants. This allows for the natural formation of a fibrin matrix—a three-dimensional scaffold that traps platelets, white blood cells, and stem cells. This fibrin network creates a sustained-release system, providing longer-lasting stimulation to your skin.

The fundamental distinction comes down to composition and delivery: PRP delivers growth factors immediately, while PRF creates a biological scaffold that releases growth factors gradually over time, mimicking the body’s natural healing process more closely.

How the Microneedling Process Works

The combination of microneedling with platelet-rich therapies creates a powerful synergy for skin rejuvenation. Here’s a step-by-step breakdown of what to expect during both procedures:

Step 1: Consultation and Preparation
Before either treatment, you’ll have a thorough consultation with a skincare professional to assess your skin concerns, medical history, and treatment goals. On treatment day, your skin will be cleansed thoroughly, and a topical numbing cream may be applied to ensure comfort during the procedure.

Step 2: Blood Draw
For both PRP and PRF treatments, a small amount of blood is drawn from your arm—typically about 15-30 milliliters, similar to a standard blood test.

Step 3: Centrifugation and Separation
This is where the processes diverge significantly:

For PRP: Your blood sample is placed in a specialized tube containing anticoagulants and spun at high speeds (approximately 2,000-3,000 RPM) for 8-15 minutes. This rapid spin separates the blood into three distinct layers: red blood cells at the bottom, platelet-poor plasma at the top, and the platelet-rich plasma in the middle layer, which is extracted for treatment.
For PRF: Your blood is collected in tubes without anticoagulants and centrifuged at a much slower speed (approximately 1,200-1,500 RPM) for 12-15 minutes. This gentle process allows the natural formation of the fibrin matrix, creating a three-layered structure: red blood cells at the bottom, acellular plasma at the top, and the PRF clot in the middle.

Step 4: Microneedling Treatment
While your blood is being processed, the microneedling procedure begins. A medical professional uses a sterile device containing fine needles to create microscopic channels in your skin. This process, known as collagen induction therapy, stimulates your skin’s natural healing response without causing significant damage.

Step 5: Application of PRP or PRF
The concentrated platelet solution is then applied to your freshly microneedled skin. For PRP, the liquid solution is typically painted onto the skin or applied with a roller. For PRF, the fibrin matrix may be converted into a gel or liquid form (often called i-PRF) for easy application, or in some cases, the solid PRF membrane may be placed directly on specific treatment areas.

The entire process typically takes 60-90 minutes from start to finish, with minimal discomfort thanks to the numbing cream applied beforehand.

PRF vs PRP Microneedling: Key Differences

Understanding the distinctions between these two treatments is crucial for making an informed decision. The table below highlights the core differences:

Feature	PRP Microneedling	PRF Microneedling
Additives	Uses anticoagulants	100% natural – no additives
Centrifugation Speed	Fast spin (2,000-3,000 RPM)	Slow spin (1,200-1,500 RPM)
Growth Factor Release	Immediate burst	Slow & sustained (7-14 days)
White Blood Cells	Minimal	Significant concentration
Fibrin Matrix	No natural scaffold	Rich 3D fibrin network
Platelet Concentration	High	Moderate but more natural
Results Duration	6-12 months	12-18 months
Cost per Session	$500–$900	$700–$1,200

The difference between PRF and PRP extends beyond the preparation method. PRF’s slower centrifugation preserves more white blood cells, which play a crucial role in the immune response and healing process. The fibrin matrix in PRF acts as a natural scaffold that not only prolongs the release of growth factors but also provides structural support during the healing process.

Another significant distinction is the inclusion of stem cells in PRF. The fibrin network traps mesenchymal stem cells, which have the potential to differentiate into various cell types, potentially enhancing the regenerative effects beyond what PRP can achieve.

Benefits of PRF Microneedling

PRF microneedling offers several advantages that make it an attractive option for those seeking comprehensive skin rejuvenation:

Natural Collagen & Elastin Production
The sustained release of growth factors from the fibrin matrix provides continuous stimulation to fibroblasts—the cells responsible for producing collagen and elastin. This leads to gradual, natural-looking improvement in skin firmness and elasticity that continues to develop over several months.
Longer-Lasting Results
Due to the prolonged release of growth factors, PRF microneedling benefits include results that can last significantly longer than traditional PRP treatments. While individual results vary, many patients enjoy improved skin quality for 12-18 months before considering maintenance treatments.
Comprehensive Skin Improvement
PRF addresses multiple signs of aging simultaneously. Patients typically notice improvement in skin texture, reduction in fine lines and wrinkles, diminished acne scars, and more even skin tone and pigmentation.
100% Natural – No Additives
Since PRF requires no anticoagulants or other additives, it’s considered a completely natural treatment using only your body’s own healing components. This reduces any risk of allergic reactions or adverse responses to foreign substances.
Enhanced Wound Healing Properties
The significant concentration of white blood cells in PRF enhances its anti-inflammatory and antimicrobial properties, potentially leading to faster recovery and reduced risk of complications.
Superior Structural Support
The fibrin matrix in PRF provides a scaffold that supports tissue regeneration at a structural level, potentially leading to more significant improvement in depressed scars and skin laxity.

Benefits of PRP Microneedling

While PRF offers advanced benefits, PRP microneedling remains a valuable treatment with its own set of advantages:

Proven Track Record
PRP has been used in various medical fields for decades and in dermatology for over 15 years. Its safety and efficacy are well-documented across numerous clinical studies, giving patients confidence in its established history.
Immediate Growth Factor Release
The rapid release of growth factors following PRP application can lead to quicker initial results. Many patients notice improved skin radiance and texture within the first few weeks after treatment.
Lower Cost Point
With PRF microneedling cost typically being higher, PRP offers a more budget-friendly entry point into platelet-enhanced microneedling treatments. This makes it accessible to a wider range of patients.
Excellent for Mild to Moderate Concerns
For patients with early signs of aging or mild skin texture issues, PRP—often combined with anti-aging microneedling—provides significant improvement without the higher investment of PRF treatments.
Wider Availability
Since PRP has been available longer, more practitioners are trained and equipped to offer PRP microneedling, making it easier to find providers in various locations.
Shorter Processing Time
The faster centrifugation process means less wait time during your treatment appointment, which can be convenient for patients with busy schedules.

Which One Is Better? Making the Right Choice

The question of which treatment is superior doesn’t have a one-size-fits-all answer. The best choice depends on your specific skin concerns, budget, and desired outcomes.

“For most patients, PRF offers longer-lasting results and deeper rejuvenation due to its natural fibrin matrix and gradual release of growth factors.”

However, this doesn’t mean PRP is obsolete. PRP remains an excellent choice for:

First-time patients wanting to experience platelet-enhanced microneedling
Those with budget constraints
Patients with mild skin concerns needing refreshment rather than significant rejuvenation
Younger patients focusing on prevention and maintenance

PRF tends to be more beneficial for:

Patients seeking maximum results and longevity
Those addressing significant concerns like deep wrinkles, substantial volume loss, or pronounced scarring
Individuals wanting the most natural approach without additives
Patients willing to invest more for potentially superior outcomes

It’s worth noting that some practices offer combination approaches, using both PRP and PRF in the same treatment session to leverage the benefits of both—the immediate growth factor release from PRP and the sustained benefits from PRF.

Results & Recovery: What to Expect

Understanding the recovery process and realistic expectations for results is crucial for both treatments.

Immediate Post-Treatment Period (Days 1-3)
After either PRP or PRF microneedling, your skin will appear red and flushed, similar to a moderate sunburn. This is completely normal and typically subsides within 24-72 hours. You might experience slight swelling and sensitivity, which usually resolves quickly. Most people can return to normal activities the next day, though you may want to avoid significant social events during the initial redness phase.
The First Week
Within 3-5 days, the initial redness fades, and your skin may feel dry and begin to peel slightly. This is part of the natural healing process as old skin cells shed and new ones emerge. It’s crucial to use gentle, hydrating skincare products and avoid exfoliants during this time.
Visible Improvements
Initial PRP microneedling results often include improved skin radiance and texture within 2-3 weeks. For both treatments, more significant improvements in fine lines, pores, and skin tightness typically become noticeable around 4-6 weeks as new collagen formation accelerates.
Long-Term Transformation
The most dramatic results develop over 2-3 months as collagen remodeling continues. Many patients opt for a series of 2-3 treatments spaced 4-6 weeks apart for optimal results, followed by maintenance sessions once or twice a year.
Maintenance and Skincare
To maximize and maintain your results, consistent skincare is essential. This includes daily sunscreen use, adequate hydration, and products that support skin health, such as vitamin C serums and retinoids (once fully healed and with your provider’s approval).

PRF vs PRP Cost in the USA

The financial investment is an important consideration when choosing between these treatments. Several factors influence the cost, including geographic location, practitioner expertise, and the specific concerns being addressed.

PRP Microneedling Cost
The average cost for a single PRP microneedling session in the United States ranges from $500 to $900. Most practitioners recommend a series of 2-3 initial treatments for optimal results, bringing the total initial investment to approximately $1,000 to $2,700.
PRF Microneedling Cost
PRF microneedling cost typically ranges from $700 to $1,200 per session. The higher price reflects the more advanced technology, longer processing time, and potentially superior results. A series of three treatments would therefore cost between $2,100 and $3,600.

Factors Influencing Cost:

Practitioner Expertise: Board-certified dermatologists or plastic surgeons typically charge more than medspa practitioners
Geographic Location: Prices in major metropolitan areas (New York, Los Angeles, Miami) are generally higher than in smaller cities
Treatment Area: Larger treatment areas or combination treatments (face and neck) cost more
Technology Used: Advanced microneedling devices like RF microneedling with PRP/PRF command premium prices

While the upfront cost of PRF is higher, its longer-lasting results may make it more cost-effective over time compared to PRP, which may require more frequent maintenance sessions.

Who Is a Good Candidate?

Both PRP and PRF microneedling are suitable for a wide range of patients seeking natural growth factor skin rejuvenation. Ideal candidates typically include:

Good candidates for both treatments:

Individuals with fine lines and wrinkles
Those with dull, tired-looking skin seeking improved radiance
People with mild to moderate skin laxity
Patients with acne scars or other textural concerns
Those seeking natural alternatives to synthetic fillers or aggressive procedures
Individuals with generally good health and realistic expectations

Poor candidates may include:

People with active skin infections or inflammation
Those with blood disorders or bleeding conditions
Individuals taking blood thinners (requires physician clearance)
Patients with unrealistic expectations
People with a history of poor wound healing or keloid scarring
Those who are pregnant or breastfeeding

It’s essential to have a thorough consultation with a qualified provider who can assess your specific situation and recommend the most appropriate treatment based on your skin type, concerns, and medical history.

Frequently Asked Questions

Is PRF better than PRP for microneedling?
For most patients seeking optimal and long-lasting results, PRF does offer advantages over PRP due to its sustained growth factor release and natural composition. However, PRP remains an effective treatment, particularly for milder concerns or budget-conscious patients. The “better” option depends on your specific goals, skin condition, and priorities.

How long do PRF microneedling results last?
PRF microneedling results typically last 12-18 months, though this varies based on individual factors like age, skin condition, lifestyle, and how many treatments you’ve had. With a series of treatments and proper maintenance, results can be prolonged significantly. The collagen remodeling stimulated by the treatment provides lasting improvement even after the growth factors have dissipated.

Can I combine PRF with other treatments?
Yes, PRF can be effectively combined with other aesthetic treatments for enhanced results. Common combinations include PRF with radiofrequency microneedling for additional skin tightening, or with laser treatments for comprehensive rejuvenation. However, these combinations should be performed by experienced practitioners who understand proper timing and sequencing to maximize benefits while minimizing risks.

Is PRF microneedling painful?
Most patients describe the sensation as manageable rather than painful. A topical numbing cream is applied before the microneedling process, which significantly reduces discomfort. During the procedure, you may feel a vibrating sensation or mild prickling. After treatment, your skin will feel warm and sensitive, similar to a sunburn, but this typically resolves within hours to a day.

How many sessions are recommended?
For both PRP and PRF microneedling, most practitioners recommend an initial series of 2-3 treatments spaced 4-6 weeks apart for optimal results. After the initial series, maintenance treatments every 6-12 months for PRP or 12-18 months for PRF help sustain and build upon your results. The exact number depends on your specific concerns, skin response, and desired outcome.

Bottom Line

The choice between PRF vs PRP microneedling represents an important decision in your skin rejuvenation journey. Both treatments offer significant benefits by harnessing your body’s natural healing capabilities, but they differ in their approach and results.

Ultimately, the best choice depends on your individual skin concerns, budget, and expectations. Consulting with an experienced, qualified provider who understands both technologies is the most important step in determining which approach is right for you.

Ready to experience the next generation of natural skin repair treatments? Book your PRF microneedling consultation with Eye Candy Med Beauty today and discover which treatment is ideal for your skin goals.